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MSE PRO 2-(Dicyclohexylphosphino)-2',4',6'-triisopropylbiphenyl– MSE Supplies LLC

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MSE PRO 2-(Dicyclohexylphosphino)-2',4',6'-triisopropylbiphenyl (XPhos), 98% Purity - MSE Supplies LLC

MSE PRO 2-(Dicyclohexylphosphino)-2',4',6'-triisopropylbiphenyl (XPhos), 98% Purity

SKU: CM1310

  • $ 28795
  • Save $ 3195

MSE PRO™ 2-(Dicyclohexylphosphino)-2',4',6'-triisopropylbiphenyl (XPhos), 98% Purity

MSE PRO™ 2-(Dicyclohexylphosphino)-2',4',6'-triisopropylbiphenyl (XPhos) is a highly effective ligand in Pd-catalyzed amination and amidation reactions of aryl sulfonates. XPhos serves as a crucial reagent in the production of novel [1,2,4]triazolo[4,3-a]pyrazine derivatives, which have potential as selective c-met inhibitors with improved pharmacokinetic properties.

MSE Supplies offers various catalysts and ligands of coupling reaction. Please contact us for customization or bulk orders.

Technical Specifications:

CAS No. 564483-18-7
EINECS No. 611-387-6
Chemical name 2-(Dicyclohexylphosphino)-2',4',6'-triisopropylbiphenyl
Synonym(s)
  • XPhos
  • 2-(Dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1'-biphenyl
Molecular formula C33H49P
Pack size

25 g (CM1310); 100 g (CM1311)
Molecular weight 476.72 g/mol
Purity 98 %
Melting point 187-190 °C
Solubility
 		Benzene (slightly)
Appearance White powder
Storage  Inert atmosphere, room temperature


References:

[1] Naber, J. R., & Buchwald, S. L. (2008). Palladium‐Catalyzed Stille Cross‐Coupling Reaction of Aryl Chlorides using a Pre‐Milled Palladium Acetate and XPhos Catalyst System. Advanced Synthesis & Catalysis, 350(7‐8), 957-961.

[2] Wagschal, S., Perego, L. A., Simon, A., Franco‐Espejo, A., Tocqueville, C., Albaneze‐Walker, J., ... & Grimaud, L. (2019). Formation of XPhos‐Ligated Palladium (0) Complexes and Reactivity in Oxidative Additions. Chemistry–A European Journal, 25(28), 6980-6987.