MSE PRO 2-Dicyclohexylphosphino-2', 6'-dimethoxybiphenyl (SPhos), 98% Purity

MSE PRO™ 2-Dicyclohexylphosphino-2', 6'-dimethoxybiphenyl (SPhos), 98% Purity

MSE PRO™ [2-Dicyclohexylphosphino-2′, 6′-dimethoxybiphenyl] (SPhos) is an air-stable, electron-rich biaryl phosphine ligand developed by the Buchwald group to enhance the reactivity of palladium catalysis during cross-coupling reactions. Additionally, SPhos is a catalyst that is used in the preparation of thiadiazoles as DGAT1 inhibitors with potential in metabolic diseases treatment.

MSE Supplies offers various catalysts and ligands of coupling reaction. Please contact us for customization or bulk orders.

Technical Specifications:

References:

[1] Kozuch, S., & Martin, J. M. (2011). What makes for a good catalytic cycle? A theoretical study of the SPhos ligand in the Suzuki–Miyaura reaction. Chemical communications, 47(17), 4935-4937.

[2] Prieto, M., Mayor, S., Lloyd-Williams, P., & Giralt, E. (2009). Use of the SPhos ligand to suppress racemization in arylpinacolboronate ester Suzuki couplings involving α-amino acids. Synthesis of biaryl derivatives of 4-hydroxyphenylglycine, tyrosine, and tryptophan. The Journal of Organic Chemistry, 74(23), 9202-9205.