MSE PRO tert-Butyl 7-oxo-2,6-diazaspiro[3.4]octane-2-carboxylate, ≥98.0% Purity

MSE PRO™ tert-Butyl 7-oxo-2,6-diazaspiro[3.4]octane-2-carboxylate, ≥98.0% Purity

MSE PRO™ tert-Butyl 7-oxo-2,6-diazaspiro[3.4]octane-2-carboxylate is a versatile and valuable synthetic intermediate for organic synthesis. As a spirocyclic compound, it possesses a unique rigid bicyclic structure with a fused diazaspiro ring system. This structural motif is prevalent in many bioactive molecules and drug candidates, making it an attractive building block for medicinal chemistry applications. The presence of the tert-butyl carbamate protecting group allows for selective deprotection under mild acidic conditions, revealing a reactive amine functionality for further derivatization. This feature enables the controlled introduction of diverse substituents, facilitating the synthesis of complex heterocyclic scaffolds with potential biological activities.

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Technical Specifications:

References:

[1] Fu, K., Xu, W., Yang, R., Zhao, H., Xu, H., Wei, Y., ... & Xiong, B. (2023). 2, 6-diazaspiro [3.4] octan-7-one derivatives as potent sigma-1 receptor antagonists that enhanced the antinociceptive effect of morphine and rescued morphine tolerance. European Journal of Medicinal Chemistry, 249, 115178.

[2] Martínez-Viturro, C. M., Trabanco, A. A., Royes, J., Fernández, E., Tresadern, G., Vega, J. A., ... & Bartolomé-Nebreda, J. M. (2020). Diazaspirononane nonsaccharide inhibitors of O-GlcNAcase (OGA) for the treatment of neurodegenerative disorders. Journal of medicinal chemistry, 63(22), 14017-14044.