PLEKHO1 Polyclonal Antibody
SKU: E-AB-11086-200
PLEKHO1 Polyclonal Antibody
| SKU # | E-AB-11086 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Applications | WB, IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human PLEKHO1 |
| Abbre | PLEKHO1 |
| Synonyms | C-Jun-binding protein, CK2 interacting protein 1, CK2 interacting protein 1 HQ0024c protein, CK2-interacting protein 1, CKIP 1, CKIP-1, CKIP1, Casein kinase 2-interacting protein 1, JBP, OC120, Osteoclast maturation, Osteoclast maturation associated gene 120 protein |
| Swissprot | |
| Calculated MW | 46 kDa |
| Cellular Localization | Cell membrane. Nucleus. Cytoplasm. Predominantly localized to the plasma membrane. In C2C12 cells, with the absence of growth factor, it is found in the nucleus. It rapidly translocates to the plasma membrane after insulin stimulation. In response to TNF, it translocates from the plasma membrane to the cytoplasm and then to the nucleus accompanied by cleavage by caspase-3. However, the subcellular location is highly dependent of the cell type, and this explains why it is found exclusively at the plasma membrane, in some type of cells. |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:200-1:1000 |
| IHC | 1:100-1:300 |
Background
Pleckstrin homology domain-containing family O member 1 is a protein that in humans is encoded by thePLEKHO1 gene.Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP).May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2).Appears to target ATM to the plasma membrane.Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival.