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Recombinant Cynomolgus macaques CD38/ADPRC1 protein (His tag)
SKU: PDEC100002-100
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Recombinant Cynomolgus macaques CD38/ADPRC1 protein (His tag)
| SKU # | PDEC100002 |
| Expression Host | E. coli |
Description
| Synonyms | ADP-ribosyl cyclase 1;cyclic ADP-ribose hydrolase;CD38;T10 |
| Species | Cynomolgus macaques |
| Expression_host | E.coli |
| Sequence | Leu 44-Ile 301 |
| Accession | Q5VAN0 |
| Mol_Mass | 28.3 kDa |
| AP_Mol_Mass | 32 kDa |
| Tag | N-His |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis |
Background
CD38, also called ADP-ribosyl cyclase, is a Type II integral membrane protein with 301 amino acids in length that belongs to the ADP-ribosyl cyclase family.It synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. And also moonlights as a receptor in cells of the immune system. CD38 is expressed in B and T lymphocytes, osteoclasts, and in cardiac, pancreatic, liver and kidney cells. Through its production of cyclic ADP-ribose, CD38 modulates calcium-mediated signal transduction in many types of cells, including neutrophils and pancreatic beta cells.