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Recombinant Human AKR1C4 Protein (His Tag)
SKU: PKSH032056-50
Recombinant Human AKR1C4 Protein (His Tag)
| SKU # | PKSH032056 |
| Expression Host | E.coli |
Description
| Synonyms | 3-Alpha-HSD1, 3-Alpha-Hydroxysteroid Dehydrogenase Type I, AKR1C4, Aldo-Keto Reductase Family 1 Member C4, CDR, CHDR, Chlordecone Reductase, DD-4, DD4, Dihydrodiol Dehydrogenase 4, HAKRA |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Tyr323 |
| Accession | P17516 |
| Calculated Molecular Weight | 39.3 kDa |
| Observed Molecular Weight | 35-40 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0. |
| Reconstitution | Not Applicable |
Background
Aldo-Keto Reductase 1C4/AKR1C4 is a member of the aldo/keto reductase family that consists of more than 40 known enzymes and proteins. AKR1C4 has highly expressed in Liver. It can catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. AKR1C4 catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-α-Androstan-3-α,17-β-diol (3-α-diol). In addition, AKR1C4 also has some 20-α-Hydroxysteroid Dehydrogenase activity.