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Recombinant Human ALK4/ACVR1B Protein (His Tag)(Active)
SKU: PKSH032037-50
Recombinant Human ALK4/ACVR1B Protein (His Tag)(Active)
| SKU # | PKSH032037 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | ACTR-IB, ACVR1B, ACVRLK4, ALK-4, ALK4, Activin Receptor Type IB, Activin Receptor Type-1B, Activin Receptor-Like Kinase 4, SKR2, Serine/Threonine-Protein Kinase Receptor R2 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Ser24-Glu126 |
| Accession | P36896 |
| Calculated Molecular Weight | 12.5 kDa |
| Observed Molecular Weight | 14-20 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Activin Receptor Type-1B (ACVR1B) is a single-pass type I membrane protein that belongs to the protein kinase superfamily. ACVR1B contains one GS domain and one protein kinase domain and is expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver. ACVR1B acts as a transducer of activin or activin like ligands signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B, ACVR2A or ACVR2B activating ACVR1B through phosphorylation of its regulatory GS domain. They go on to recruit the R-SMADs, SMAD2 and SMAD3. ACVR1B also transducers signals of nodal, GDF-1, and Vg1. Mutations in ACVR1B are associated with pituitary tumors.