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Recombinant Human Angiotensinogen/AGT Protein (His Tag)
SKU: PKSH032069-50
Recombinant Human Angiotensinogen/AGT Protein (His Tag)
| SKU # | PKSH032069 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | AGT and SERPINA8, ANHU, Angiotensinogen, Serpin A8 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Asp34-Ala485 |
| Accession | AAH11519.1 |
| Calculated Molecular Weight | 50.8 kDa |
| Observed Molecular Weight | 55-75 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
| Reconstitution | Not Applicable |
Background
Angiotensinogen is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Genetic variations in Angiotensinogen are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in the encoding gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.