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Recombinant Human Arginase-1/ARG1 Protein (E.coli, His Tag)(Active)
SKU: PKSH032091-50
Recombinant Human Arginase-1/ARG1 Protein (E.coli, His Tag)(Active)
| SKU # | PKSH032091 |
| Expression Host | E.coli |
Description
| Synonyms | ARG1, Arginase-1, Liver-type arginase, Type I arginase |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-lys322 |
| Accession | P05089 |
| Calculated Molecular Weight | 35.8 kDa |
| Observed Molecular Weight | 40 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 20% Glycerol, 1mM DTT, pH 7.4. |
| Reconstitution | Not Applicable |
Background
ARG1 is a member of the ureohydrolase family of enzymes. ARG1 can catalyze the hydrolysis of arginine to ornithine and urea. In the urea cycle, ARG1 catalyzes the fifth and final step, a series of biochemical reactions in mammals during which the body disposes of harmful ammonia. ARG1 is a cytosolic enzyme and expressed widely in the liver as part of the urea cycle. Inherited deficiency of this ARG1 causes argininemia, which is an autosomal recessive disorder characterized by hyperammonemia.