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Recombinant Human BCL-W/BCL2L2 Protein (His Tag)
SKU: PKSH032116-50
Recombinant Human BCL-W/BCL2L2 Protein (His Tag)
| SKU # | PKSH032116 |
| Expression Host | E.coli |
Description
| Synonyms | Apoptosis Regulator Bcl-W, BCL2L2, BCLW, Bcl-2-Like Protein 2, Bcl2-L-2, KIAA0271 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Ala2-Thr172 |
| Accession | AAI13523.1 |
| Calculated Molecular Weight | 19.9 kDa |
| Observed Molecular Weight | 18 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 25mM HEPES, 100mM KCl, 20% Glycerol, pH 7.5. |
| Reconstitution | Not Applicable |
Background
Bcl-2-like protein 2 (BCL2L2) belongs to the Bcl-2 family. BCL2L2 is highly expressed in thebrain, spinal cord, testis, pancreas, heart, spleen, and mammary glands. BCL2L2 is a peripheral membrane protein containing three motifs, BH1, BH2 and BH4. The BH4 motif appears to be involved in the anti-apoptotic function. The BH1 and BH2 motifs form a hydrophobic groove which acts as a docking site for the BH3 domain of some pro-apoptotic proteins. BCL2L2 promotes cell survival and blocks dexamethasone-induced apoptosis. Furthermore, BCL2L2 mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.