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Recombinant Human C1QBP Protein (aa 74-282, His Tag)
SKU: PKSH033350-50
Recombinant Human C1QBP Protein (aa 74-282, His Tag)
| SKU # | PKSH033350 |
| Expression Host | E.coli |
Description
| Synonyms | ASF/SF2-Associated Protein p32, C1QBP, C1qBP, Complement Component 1 Q Subcomponent-Binding Protein Mitochondrial, GC1QBP, Glycoprotein gC1qBP, HABP1, Hyaluronan-Binding Protein 1, Mitochondrial Matrix Protein p32, SF2P32, gC1q-R Protein, gC1qR, p33 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Leu74-Gln282 |
| Accession | Q07021 |
| Calculated Molecular Weight | 24.9 kDa |
| Observed Molecular Weight | 34 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 20% Glycerol, 1mM DTT, pH 7.5. |
| Reconstitution | Not Applicable |
Background
Complement Component 1Q Subcomponent-Binding Protein (C1QBP) is a nucleus protein that belongs to the MAM33 family. C1QBP is known to bind to the globular heads of C1q molecules and inhibit C1 activation. Mitochondrial C1QBP is a critical mediator of p14ARF-induced apoptosis. C1QBP functions as a chemotactic factor for immature dendritic cells, and migration is mediated through ligation of both C1QBP and cC1qR/CR. C1QBP overexpression successfully blocks mRNA accumulation from the adenovirus major late transcription unit (MLTU) and stimulates RNA polymerase II carboxy-terminal domain phosphorylation in virus-infected cells.