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Recombinant Human CA11 Protein (His Tag)
SKU: PKSH032166-50
Recombinant Human CA11 Protein (His Tag)
| SKU # | PKSH032166 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | CA-RP II, CA-RP XI, CA-XI, CA11, CARP XI, CARP-2, CARP2, Carbonic Anhydrase-Related Protein 11, Carbonic Anhydrase-Related Protein 2 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | His24-Arg328 |
| Accession | O75493 |
| Calculated Molecular Weight | 35.1 kDa |
| Observed Molecular Weight | 38 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
| Reconstitution | Not Applicable |
Background
Carbonic Anhydrase-Related Protein 11 (CA11) is a secreted protein member of the α-carbonic anhydrase family. Carbonic Anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. CA11 is expressed abundantly in the brain with moderate expression also present in spinal cord and thyroid. CA11 may play a general role in the central nervous system.