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Recombinant Human Cardiotrophin-1/CTF1 Protein (His Tag)
SKU: PKSH032175-50
Recombinant Human Cardiotrophin-1/CTF1 Protein (His Tag)
| SKU # | PKSH032175 |
| Expression Host | E.coli |
Description
| Synonyms | CT-1, CTF1, Cardiotrophin-1 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Ala201 |
| Accession | Q16619 |
| Calculated Molecular Weight | 22.6 kDa |
| Observed Molecular Weight | 25 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, 2mM EDTA, 5% Trehalose, pH 7.4. |
| Reconstitution | Not Applicable |
Background
Cardiotrophin-1, also known as CT-1 and CTF1, is a member of the IL-6 superfamily. It is a sreted cytokine that is expressed in heart, skeletal muscle, prostate and ovary, and to lower levels in lung, kidney, pancreas, thymus, testis and small intestine. The protein exerts its cellular effects by interacting with the glycoprotein 130 (gp130)/leukemia inhibitory factor receptor beta (LIFR) heterodimer. In addition, CT-1 activates phosphatidylinositol 3-kinase (PI-3 kinase) in cardiac myocytes and enhances transcription factor NF-κB DNA -binding activities.