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Recombinant Human CC16 Protein (His tag)
SKU: PDMH100049-100
Recombinant Human CC16 Protein (His tag)
| SKU # | PDMH100049 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | CC10, CCPBP, CCSP, Clara cell phospholipid-binding protein, Clara cells 10 kDa secretory protein, SCGB1A1, Secretoglobin family 1A member 1, UGB, UP-1, UP1, Urinary protein 1, Urine protein 1, Uteroglobin |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Glu22-Asn91 |
| Accession | P11684 |
| Calculated Molecular Weight | 9.9 kDa |
| Observed Molecular Weight | 10 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | Please contact us for more information. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis |
Background
Uteroglobin is a small; non-glycosylated secreted protein of the secretoglobin superfamily. It is produced by the non-ciliated; non-mucous secretory cells that predominate in lung bronchioles (Clara cells); and other non-ciliated epithelia that communicate with the external environment. Expression is induced by steroid hormones such as estrogen; and enhanced by the non-steroid hormone prolactin. Human Uteroglobin cDNA encodes a 21 amino acid (aa) signal sequence and a 70 aa mature protein. The mature protein forms a disulfide-linked head-to-tail homodimer of 16 kDa. This homodimer is thought to form a binding pocket that binds hydrophobic ligands such as phospholipids; progesterone and retinols. Binding of fibronectin to Uteroglobin in the kidney is thought to protect against nephropathy; while binding of the lipocalin-1 receptor has been reported to suppress cancer cell motility and invasion.