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Recombinant Human CCL18 Protein (His Tag)
SKU: PKSH032189-50
Recombinant Human CCL18 Protein (His Tag)
| SKU # | PKSH032189 |
| Expression Host | E.coli |
Description
| Synonyms | AMAC-1, Alternative Macrophage Activation-Associated CC Chemokine 1, C-C Motif Chemokine 18, CC Chemokine PARC, DC-CK1, Dendritic Cell Chemokine 1, MIP-4, Macrophage Inflammatory Protein 4, Pulmonary and Activation-Regulated Chemokine, Small-Inducible Cytokine A18 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Ala21-Ala89 |
| Accession | P55774 |
| Calculated Molecular Weight | 10.1 kDa |
| Observed Molecular Weight | 13 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
C-C Motif Chemokine 18 (CCL18) is secreted protein that belongs to the intercrine beta (chemokine CC) family. CCL18 is expressed at high levels in the lung, lymph nodes, placenta, bone marrow, and dendritic cells. CCL18 is a chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. CCL18 may be involved in B-cell migration into B-cell follicles in lymph nodes. CCL18 attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role in both humoral and cell-mediated immunity responses.