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Recombinant Human CD200R1 Protein (Fc Tag)
SKU: PKSH032207-50
Recombinant Human CD200R1 Protein (Fc Tag)
| SKU # | PKSH032207 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | CD200 Cell Surface Glycoprotein Receptor, CD200R, CD200R1, CRTR2, Cell Surface Glycoprotein CD200 Receptor 1, Cell Surface Glycoprotein OX2 Receptor 1, MOX2R, OX2R |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Ala27-Leu266 |
| Accession | Q8TD46 |
| Calculated Molecular Weight | 53.9 kDa |
| Observed Molecular Weight | 70-105 kDa |
| Tag | C-Fc |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Cell surface glycoprotein CD200 Receptor 1 (CD200R1) is the receptor for the CD200 (OX-2) membrane glycoprotein. CD200R1 contains one C2- type Ig-like domain and one V-type Ig-like domain within its extracellular domain and a PTB-signaling motif in cytoplasmic domain. CD200R1 and CD200 associate via their respective N-terminal Ig-like domains. CD200R1 is restricted primarily to mast cells, basophils, macrophages, and dendritic cells. It propagates inhibitory signals despite its lacking a cytoplasmic ITIM (immunoreceptor tyrosinebased inhibitory motif). The receptor-substrate interaction may function as a myeloid downregulatory signal.