Total Price: $0.00
Contact Information
Recombinant Human CD226/DNAM-1 Protein (Fc Tag)(Active)
SKU: PKSH033729-50
To better serve you, we would like to discuss your specific requirement.
Please Contact Us for a quote.
Recombinant Human CD226/DNAM-1 Protein (Fc Tag)(Active)
| SKU # | PKSH033729 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | CD226, CD226 antigen, DNAM-1, DNAM1, DNAX accessory molecule 1 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Glu19-Asn247 |
| Accession | Q15762 |
| Calculated Molecular Weight | 52.8 kDa |
| Observed Molecular Weight | 72-90 kDa |
| Tag | C-Fc |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Human DNAX accessory molecule 1 (DNAM-1/CD226) is a 65 kDa type I transmembrane glycoprotein in the immunoglobulin superfamily. Mature human DNAM-1 contains an extracellular domain (ECD) with two Ig-like C2-set domains and a cytoplasmic region that contains motifs for binding PDZ domains and band 4.1 family proteins. DNAM-1 is expressed on multiple lymphoid and myeloid cells and interacts with CD155 and CD112. Ligation of DNAM-1 promotes the activation of NK cells; CD8+ T cells; and mast cells; dendritic cell maturation; megakaryocyte and activated platelet adhesion to vascular endothelial cells; and monocyte extravasation; it inhibits the forrmation of osteoclasts. Plateletendothelium; interactions mediated by DNAM-1; enable the metastasis of tumor cells to the lung.