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Recombinant Human CD24 Protein (Ser27-Gly59,Ser44Thr)(Fc Tag)
SKU: PKSH033527-50
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Recombinant Human CD24 Protein (Ser27-Gly59,Ser44Thr)(Fc Tag)
| SKU # | PKSH033527 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | CD24, CD24A, FLJ22950, FLJ43543, MGC75043, Signal transducer CD24, Small cell lung carcinoma cluster 4 antigen |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Ser27-Gly59(Ser44Thr) |
| Accession | P25063 |
| Calculated Molecular Weight | 29.8 kDa |
| Observed Molecular Weight | 40-55 kDa |
| Tag | C-Fc |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Signal Transducer CD24 is a heavily and variably glycosylated GPI-linked sialoprotein. Human CD24 is expressed on B lineage cells and granulocytes, on epithelial, neuronal, and muscle cells, and on a range of tumor cells. CD24 expression is regulated during lineage development and with the activation of various cell types. Antibody crosslinking of CD24 enhances the induction of apoptosis in B and T lymphocytes which contributes to negative selection and the induction of immune tolerance. CD24 on antigen presenting cells cooperates with B7 molecules in the costimulation of T cells. CD24 associates in cis with Siglec10 and with the danger-associated molecules HMGB1, HSP70, or HSP90 which are released from necrotic or damaged cells. Formation of these ternary complexes fills a protective role: the resulting Siglec10 signaling inhibits inflammatory responses that are otherwise induced by extracellular DAMPs.