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Recombinant Human CEACAM3/CD66d Protein (His Tag)
SKU: PKSH032235-50
Recombinant Human CEACAM3/CD66d Protein (His Tag)
| SKU # | PKSH032235 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | CD66D, CD66d, CEA, CEACAM3, Carcinoembryonic Antigen CGM1, Carcinoembryonic Antigen-Related Cell Adhesion Molecule 3, MGC119875, W264, W282 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Lys35-Gly155 |
| Accession | P40198 |
| Calculated Molecular Weight | 14.1 kDa |
| Observed Molecular Weight | 15-22 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 3 (CEACAM3) belongs to the immunoglobulin superfamily and CEA family. CEACAM3 was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. CEACAM3 mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. In addition, it is associated with the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses.