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Recombinant Human CLM-9/TREM4 Protein
SKU: PKSH030648-100
Recombinant Human CLM-9/TREM4 Protein
| SKU # | PKSH030648 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | CD300 Antigen-Like Family Member G, CD300LG, CD300g, CLM-9, CLM9, CMRF35-Like Molecule 9, NEPMUCIN, TREM-4, TREM4, Triggering Receptor Expressed on Myeloid Cells 4 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Met 1-Arg247 |
| Accession | AAH25395.1 |
| Calculated Molecular Weight | 25.5 kDa |
| Observed Molecular Weight | 61-66 kDa |
| Tag | None |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
CLM-9, also known as TREM4, is a receptor which belongs to the TREM family. The TREM family of receptors regulates the activity of various cell types of the immune system including neutrophils, monocyte/macrophages, microglia, and dendritic cells. CLM-9 may mediate L-selectin-dependent lymphocyte rollings. It binds SELL in a calcium dependent manner. CLM-9 also binds lymphocyte which suggests that it functions in lymphocyte adhesion. The major CLM-9 transcript is expressed highly in human heart, skeletal muscle, and placenta. The mouse protein has been shown to be expressed in capillary endothelial cells. Human CLM-9 mediates the uptake of human IgA2 and mouse IgM.