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Recombinant Human Clusterin/ApoJ Protein (Fc & His Tag)
SKU: PKSH032261-50
Recombinant Human Clusterin/ApoJ Protein (Fc & His Tag)
| SKU # | PKSH032261 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | AAG4, APO-J, APOJ, Aging-Associated Gene 4 Protein, Apo-J, Apolipoprotein J, CLI, CLU, CLU1, CLU2, Clusterin, Complement Cytolysis Inhibitor, Complement-Associated Protein SP-40, KUB1, Ku70-Binding Protein 1, NA1/NA2, TRPM-2, Testosterone-Repressed Prostate Message 2 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Asp23-Glu449 |
| Accession | P10909 |
| Calculated Molecular Weight | 78.0 kDa |
| Observed Molecular Weight | 33-45&60-85 kDa |
| Tag | C-Fc-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Clusterin is a secreted protein which belongs to the Clusterin family. Clusterin is expressed in adult testis; heart; ovary; adrenal gland; brain and liver. Clusterin has been suggested to be involved in several basic biological events such as cell death; tumor progression; and neurodegenerative disorders. In addition;Clusterin is up/ down regulated on the mRNA or protein level in many pathological and clinically relevant situations including cancer; organ regeneration; infection; Alzheimer disease; retinitis pigmentosa; myocardial infarction; renal tubular damage; autoimmunity and others.