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Recombinant Human Complement Component C8 Gamma Chain/C8G Protein (His Tag)
SKU: PKSH032271-50
Recombinant Human Complement Component C8 Gamma Chain/C8G Protein (His Tag)
| SKU # | PKSH032271 |
| Expression Host | E.coli |
Description
| Synonyms | C8G, Complement component C8 gamma chain |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Gln21-Arg202 |
| Accession | AAI13627.1 |
| Calculated Molecular Weight | 22.6 kDa |
| Observed Molecular Weight | 22 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
| Reconstitution | Not Applicable |
Background
Complement component C8 is a constituent of the membrane attack complex, C8 alpha, C8 beta and C8G. C8G is a secreted protein and comsists a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain. C8 alpha and C8 beta play an important role in complement-mediated bacterial killing together.C8 is involved in the formation of Membrane Attack Complex on bacterial cell membranes. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol. Patients lacking C8 are susceptible to certain bacterial infections.