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Recombinant Human CTNNB1 Protein
SKU: PDEH100082-100
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Recombinant Human CTNNB1 Protein
| SKU # | PDEH100082 |
| Expression Host | E. coli |
Description
| Synonyms | Catenin beta-1;Beta-catenin;CTNNB;OK;SW-cl.35;PRO2286 |
| Species | Human |
| Expression_host | E.coli |
| Sequence | Met131-Tyr670 |
| Accession | P35222 |
| Mol_Mass | 59.0 kDa |
| AP_Mol_Mass | 59 kDa |
| Tag | N-His |
Properties
| Purity | > 85 % as determined by reducing SDS-PAGE. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4.5% trehalose, 5% mannitol, 0.01% Tween 80. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis |
Background
Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome.