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Recombinant Human CXCL12/SDF-1 Protein (aa22-89)
SKU: PKSH032296-50
Recombinant Human CXCL12/SDF-1 Protein (aa22-89)
| SKU # | PKSH032296 |
| Expression Host | E.coli |
Description
| Synonyms | C-X-C Motif Chemokine 12, CXCL12, IRH, Intercrine Reduced in Hepatomas, PBSF, Pre-B Cell Growth-Stimulating Factor, SDF-1, SDF1, SDF1A, SDF1B, Stromal Cell-Derived Factor 1, hIRH, hSDF-1 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Lys22-Lys89 |
| Accession | P48061 |
| Calculated Molecular Weight | 8.1 kDa |
| Observed Molecular Weight | 10 kDa |
| Tag | None |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 0.01 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Stromal Cell-Derived Factor-1 (SDF-1) is a chemokine member of the intercrine family. SDF1 is expressed as five isoforms that differ only in the C terminal tail. SDF1α and SDF1β are identical except for the four residues present in the C-terminus of SDF1β but absent from SDF1α. SDF1 isoforms interact with CXCR4 and CXCR7 receptors on the cell surface; and can also bind syndecan4. SDF1 is known to influence lymphopoiesis; regulate patterning and cell number of neural progenitors; and promote angiogenesis. It also enhances the survival of myeloid progenitor cells.