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Recombinant Human Cyclophilin D/PPID Protein (His Tag)
SKU: PKSH032874-50
Recombinant Human Cyclophilin D/PPID Protein (His Tag)
| SKU # | PKSH032874 |
| Expression Host | E.coli |
Description
| Synonyms | 40 kDa Peptidyl-Prolyl Cis-Trans Isomerase, CYP-40, CYP40, CYPD, Cyclophilin-40, Cyclophilin-Related Protein, PPID, PPIase D, Peptidyl-Prolyl Cis-Trans Isomerase D, Rotamase D |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Ala370 |
| Accession | Q08752 |
| Calculated Molecular Weight | 43.9 kDa |
| Observed Molecular Weight | 40 kDa |
| Tag | N-His & C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, 10% Glycerol, pH 7.4. |
| Reconstitution | Not Applicable |
Background
Peptidyl-Prolyl Cis-Trans Isomerase D (PPID) belongs to the cyclophilin-type PPIase family and PPIase D subfamily. PPID is widely expressed and it contains one PPIase cyclophilin-type domain and three TPR repeats. PPID catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerates the folding of proteins. PPID can bind to the immunosuppressant cyclosporine A and is known that its overexpression suppresses the apoptosis in cancer cells.