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Recombinant Human Cystatin C/CST3 Protein (His Tag)
SKU: PDEH100029-100
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Recombinant Human Cystatin C/CST3 Protein (His Tag)
| SKU # | PDEH100029 |
| Expression Host | E. coli |
Description
| Synonyms | Cys-C;CST3;Cystatin 3;ARMD11;Post-Gamma-Globulin |
| Species | Human |
| Expression_host | E.coli |
| Sequence | Ser27-Ala146 |
| Accession | P01034-1 |
| Mol_Mass | 13.3 kDa |
| AP_Mol_Mass | 14 kDa |
| Tag | N-His |
Properties
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis |
Background
Cystatin C is a member of family 2 of the cystatin superfamily. It is ubiquitous in human tissues and body fluids and mainly used as a biomarker of kidney function. Cystatin C inhibits many cysteine proteases such as papain and Cathepsins B, H, K, L and S. As an inhibitor of cysteine proteinases, Cystatin C is thought to serve an important physiological role as a local regulator of this enzyme activity. Recently, it has been studied for its role in predicting new-onset or deteriorating cardiovascular disease. It also seems to play a role in brain disorders involving amyloid (a specific type of protein deposition), such as Alzheimer's disease.