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Recombinant Human Deoxycytidine Kinase/DCK Protein (His &T7 Tag)
SKU: PKSH032348-50
Recombinant Human Deoxycytidine Kinase/DCK Protein (His &T7 Tag)
| SKU # | PKSH032348 |
| Expression Host | E.coli |
Description
| Synonyms | DCK, Deoxycytidine Kinase, dCK |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Leu260 |
| Accession | P27707 |
| Calculated Molecular Weight | 34.0 kDa |
| Observed Molecular Weight | 30 kDa |
| Tag | N-His-T7 |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, 50% Glycerol, 1mM TCEP, pH 7.4. |
| Reconstitution | Not Applicable |
Background
Deoxycytidine Kinase (DCK) is a member of the DCK/DGK family. DCK exists as a homodimer and is localized to the nucleus. DCK is required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG), and deoxyadenosine (dA). DCK has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. In addition, DCK is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents. DCK is clinically important because of its relationship to drug resistance and sensitivity.