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Recombinant Human Dipeptidase 1/DPEP1 Protein (His Tag)
SKU: PKSH032356-50
Recombinant Human Dipeptidase 1/DPEP1 Protein (His Tag)
| SKU # | PKSH032356 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | DPEP1, Dehydropeptidase-I, Dipeptidase 1, MBD1, MDP, Microsomal Dipeptidase, RDP, Renal Dipeptidase, hRDP |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Asp17-Ser385 |
| Accession | P16444 |
| Calculated Molecular Weight | 42.1 kDa |
| Observed Molecular Weight | 41 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, 10% Glycerol, pH 7.4. |
| Reconstitution | Not Applicable |
Background
Dipeptidase 1 (DPEP1) is a kidney membrane enzyme that belongs to the peptidase M19 family. DPEP1 is a homodimer and is inhibited by L-penicillamine. DPEP1 hydrolyzes a variety of dipeptides and is implicated in renal metabolism of glutathione and its conjugates. DPEP1 is responsible for hydrolysis of the beta-lactam ring of antibiotics; such as penem and carbapenem. DPEP1 may play an important role in the regulation of leukotriene activity. DPEP1 expression in cancer is significantly higher than that in normal tissue. However; DPEP1 expression decreased with pathological differentiation; lymph-node and distant metastasis.