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Recombinant Human DUSP3/VHR Protein (His Tag)
SKU: PKSH033476-50
Recombinant Human DUSP3/VHR Protein (His Tag)
| SKU # | PKSH033476 |
| Expression Host | E.coli |
Description
| Synonyms | DUSP3, Dual specificity protein phosphatase 3, Dual specificity protein phosphatase VHR, VHR, Vaccinia H1-related phosphatase |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Ser2-Pro185 |
| Accession | P51452 |
| Calculated Molecular Weight | 22.6 kDa |
| Observed Molecular Weight | 18-22 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.4. |
| Reconstitution | Not Applicable |
Background
Human DUSP3 belongs to the dual specificity protein phosphatase subfamily. DUSPs are a heterogeneous group of protein phosphatases that can dephosphorylate both phosphotyrosine and phosphoserine/phosphothreonine residues within the one substrate. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. DUSPs are major modulators of critical signalling pathways that are dysregulated in various diseases. They negatively regulate members of the mitogen-activated protein kinase superfamily; which are associated with cellular proliferation and differentiation. DUSP3 is expressed in human tissues including breast and ovarian.DUSP3 shows activity both for tyrosine-protein phosphate and serine-protein phosphate; but displays a strong preference toward phosphotyrosines. Human DUSP3 specifically dephosphorylates and inactivates ERK1 and ERK2.