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Recombinant Human EGFR/ErbB1 Protein (aa 668-1210, His&GST Tag)(Active)
SKU: PKSH030428-50
Recombinant Human EGFR/ErbB1 Protein (aa 668-1210, His&GST Tag)(Active)
| SKU # | PKSH030428 |
| Expression Host | Baculovirus-Insect Cells |
Description
| Synonyms | ERBB, ERBB1, HER1, NISBD2, PIG61, mENA |
| Species | Human |
| Expression Host | Baculovirus-Insect Cells |
| Sequence | Met 668-Ala 1210 |
| Accession | NP_005219 |
| Calculated Molecular Weight | 89.1 kDa |
| Tag | N-His-GST |
| Bio-activity | The specific activity was determined to be 105 nmol/min/mg using Poly(Glu:Tyr) 4:1 as substrate. |
| Bio-activity | The specific activity was determined to be 10 nmol/min/mg using Poly(Glu, Tyr) 4:1 as substrate. |
Properties
| Purity | > 85 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as sterile solution of 20 mM Tris, 500 mM NaCl, 10 % glycerol, pH 7.4 |
| Reconstitution | Not Applicable |
Background
As a member of the epidermal growth factor receptor (EGFR) family; EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF; amphiregulin; TGF-α; betacellulin; etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation; survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization; the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK; PI3K/PKB and STAT). In addition; EGFR signaling also has been shown to exert action on carcinogenesis and disease progression; and thus EGFR protein is proposed as a target for cancer therapy currently.