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Recombinant Human EphB4/HTK Protein (aa 563-987, His & GST Tag)(Active)
SKU: PKSH030418-50
Recombinant Human EphB4/HTK Protein (aa 563-987, His & GST Tag)(Active)
| SKU # | PKSH030418 |
| Expression Host | Baculovirus-Insect Cells |
Description
| Synonyms | HTK, MYK1, TYRO11 |
| Species | Human |
| Expression Host | Baculovirus-Insect Cells |
| Sequence | Leu563-Tyr987 |
| Accession | P54760 |
| Calculated Molecular Weight | 75.2 kDa |
| Observed Molecular Weight | 66 kDa |
| Tag | N-His-GST |
| Bio-activity | The specific activity was determined to be 47 nmol/min/mg using Poly(Glu:Tyr) 4:1 as substrate. |
Properties
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as sterile solution of 20mM Tris, 500mM NaCl, pH 8.0, 3mM DTT, 10% glycerol |
| Reconstitution | Not Applicable |
Background
Ephrin type-B receptor 4 is a protein that in humans is encoded by the EPHB4 gene. It is a single-pass type I membrane protein belonging to the ephrin receptor subfamily of protein kinase superfamily. Members of the ephrin and Eph family are local mediators of cell function through largely contact-dependent processes in development and in maturity. Furthermore, EphB4 protein and the corresponding ligand Ephrin-B2 contribute to tumor growth in various human tumors. EphB4 protein has tumor suppressor activities and that regulation of cell proliferation, extracellular matrix remodeling, and invasive potential are important mechanisms of tumor suppression. Therefore, Ephrin-B2/EphB4 may be recognized as a novel prognostic indicator for cancers.