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Recombinant Human Fas/CD95/TNFRSF6 Protein (His Tag)
SKU: PKSH033436-50
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Recombinant Human Fas/CD95/TNFRSF6 Protein (His Tag)
| SKU # | PKSH033436 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | ALPS1A, APO-1, APT1, Apo-1 antigen, Apoptosis-mediating surface antigen FAS, CD95, FAS1, FASLG receptor, FASTM, TNFRSF6 and FAS, Tumor necrosis factor receptor superfamily member 6 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Gln26-Asn173 |
| Accession | P25445 |
| Calculated Molecular Weight | 17.7 kDa |
| Observed Molecular Weight | 22-35 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
FAS is a receptor and contains three TNFR-Cys repeats and one death domain. It has been shown that FAS is involved in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. FADD (adapter molecule) recruits caspase-8 to the activated receptor, the resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases mediating apoptosis. FAS-mediated apoptosis may play a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both.