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Recombinant Human Fas Ligand / TNFSF6 (N-6His)
SKU: PKSH033886-50
Recombinant Human Fas Ligand / TNFSF6 (N-6His)
| SKU # | PKSH033886 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | APT1LG1CD95L, APTL, Apoptosis antigen ligand, CD178, CD178 antigen, CD95-L, CD95L, FASLCD95 ligand, FASLG, Fas Ligand, Fas antigen ligand, Fas ligand (TNF superfamily, TNFSF6, apoptosis (APO-1) antigen ligand 1, member 6) |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Pro134-Leu281 |
| Accession | P48023 |
| Calculated Molecular Weight | 17.7 kDa |
| Observed Molecular Weight | 20-30 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.4. |
| Reconstitution | Not Applicable |
Background
Fas ligand is also known as FasL, CD178, CD95L, or TNFSF6, is a homotrimeric type-II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. Its ability to induce apoptosis in target cells plays an important role in the development, homeostasis, and function of the immune system. Interaction of FAS with fas Ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Fas Ligand may be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both.