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Recombinant Human FBPase 1/FBP1 Protein (E. coli, His Tag)
SKU: PKSH033276-50
Recombinant Human FBPase 1/FBP1 Protein (E. coli, His Tag)
| SKU # | PKSH033276 |
| Expression Host | E.coli |
Description
| Synonyms | 6-Bisphosphatase 1, 6-Bisphosphate 1-Phosphohydrolase 1, D-Fructose-1, FBP, FBP1, FBPase 1, Fructose-1 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Ala2-Gln338 |
| Accession | P09467 |
| Calculated Molecular Weight | 37.9 kDa |
| Observed Molecular Weight | 38 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 200mM NaCl, 1mM DTT, 1mM EDTA, 20% Glycerol, pH 8.0. |
| Reconstitution | Not Applicable |
Background
Fructose-1;6-Bisphosphatase 1 (FBPase 1) is a member of the FBPase class 1 family. FBPase 1 is a gluconeogenesis regulatory protein; which catalyzes the hydrolysis of fructose 1;6-bisphosphate to fructose 6-phosphate and inorganic phosphate. FBPase 1 can assume an active R-state; or an inactive T-state. FBPase 1 deficiency is inherited as an autosomal recessive disorder mainly in the liver and causes life-threatening episodes of hypoglycemia and metabolic acidosis in newborn infants or young children. FBPase 1 coupled with phosphofructokinase (PFK) is involved in the metabolism of pancreatic islet cells.