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Recombinant Human FGF-12/FGF12 Protein (Active)
SKU: PKSH032433-50
Recombinant Human FGF-12/FGF12 Protein (Active)
| SKU # | PKSH032433 |
| Expression Host | E.coli |
Description
| Synonyms | FGF-12, FGF12, FGF12B, FHF-1, FHF1, Fibroblast Growth Factor 12, Fibroblast Growth Factor Homologous Factor 1, Myocyte-Activating Factor |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Thr181 |
| Accession | P61328-2 |
| Calculated Molecular Weight | 20.5 kDa |
| Observed Molecular Weight | 19 kDa |
| Tag | None |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, 5mM EDTA, pH 7.5. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Fibroblast Growth Factor 12 (FGF-12) is a member of the fibroblast growth factor (FGF) family. FGF-12 is probably involved in nervous system development and function. FGF-12 lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfectedinto mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.