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Recombinant Human FRZB/sFRP-3 Protein (His Tag)– MSE Supplies LLC

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Recombinant Human FRZB/sFRP-3 Protein (His Tag)

SKU: PKSH031646-50

  • $ 65895
  • Save $ 7400



Recombinant Human FRZB/sFRP-3 Protein (His Tag)

 

SKU # PKSH031646
Expression Host HEK293 Cells

 

 

Description

Synonyms FRE, FRITZ, FRP-3, FRZB-1, FRZB-PEN, FRZB1, FZRB, OS1, SFRP3, SRFP3, hFIZ
Species Human
Expression Host HEK293 Cells
Sequence Ala32-Asn325
Accession NP_001454.2
Calculated Molecular Weight 34.5 kDa
Observed Molecular Weight 41 kDa
Tag C-His
Bio-activity Not validated for activity
  

 

Properties

Purity > 85 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from sterile PBS, pH 7.4
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.



Background

FRZB also known as sFRP-3, is a secreted protein containing a domain similar to the putative Wnt-binding region of the frizzled family of transmembrane receptors. FRZB is widely expressed in adult mammalian tissues. In the Xenopus gastrula, FRZB is regulated as a typical Spemann organizer component. FRZB also functions as a competitor for the cell-surface G-protein receptor Frizzled. It is espically important in embryonic development. Defects in FRZB gene can cause female-specific osteoarthritis (OA) susceptibility. FRZB may serve an important role in determining hip shape and may modify the relationship between hip shape and OA.