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Recombinant Human GABRβ3(GABRB3) protein (His tag)
SKU: PDEH100311-100
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Recombinant Human GABRβ3(GABRB3) protein (His tag)
| SKU # | PDEH100311 |
| Expression Host | E. coli |
Description
| Synonyms | Gamma-aminobutyric acid receptor subunit beta-3;GABRB3;GABA(A) receptor subunit beta-3;GABRB3 |
| Species | Human |
| Expression_host | E.coli |
| Sequence | Ser 26-Tyr 245 |
| Accession | P28472 |
| Mol_Mass | 24.1 kDa |
| AP_Mol_Mass | 32 kDa |
| Tag | N-His & C-His |
| Bio_Activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin level | Please contact us for more information. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis |
Background
γ-aminobutyric acid type A receptor β3 subunit (GABRB3) is a candidate gene for autism spectrum conditions (ASC). Alteration in the gene results in increased tactile sensitivity, or hypersensitivity.Overexpression of GABRB3 might be implicated in the pathogenesis of heroin dependence. Aberration or mutation of this gene leads to neurodevelopmental disorders, such as Angelman syndrome, Prader-Willi syndrome and schizophrenia.[1][3] GABRB3 polymorphisms results in nonsyndromic cleft lip and/or palate (NSCL/P).