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Recombinant Human Galectin-9/LGALS9 (N-GST)
SKU: PKSH033899-50
Recombinant Human Galectin-9/LGALS9 (N-GST)
| SKU # | PKSH033899 |
| Expression Host | E.coli |
Description
| Synonyms | Ecalectin, Gal-9, Gal-9delta5, Galectin-9, LGALS9, Tumor antigen HOM-HD-21 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met1-Thr322 |
| Accession | O00182-2 |
| Calculated Molecular Weight | 62.2 kDa |
| Observed Molecular Weight | 60 kDa |
| Tag | N-GST |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 1M PBS, 100 mM GSH, 15% Glycerol, pH 8.0. |
| Reconstitution | Not Applicable |
Background
Galectin-9 is a cytoplasmic protein that contains two galectin domains. Galectin-9 is an S-type lectin that is over-expressed in Hodgkin's disease tissue. Galectin-9 binds galactosides and has high affinity for the Forssman pentasaccharide. Galectin-9 plays a role in thymocyte-epithelial interactions relevant to the biology of the thymus and Inhibits cell proliferation. Galectin-9 is a ligand for HAVCR2/TIM3 and induces T-helper type 1 lymphocyte (Th1) death. In addition, Galectin-9 suppresses tumor cell metastasis by interfering with the associations CD44, VCAM-1, Integrin α4β1