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Recombinant Human GDF11/BMP-11 Protein
SKU: PKSH032511-50
Recombinant Human GDF11/BMP-11 Protein
| SKU # | PKSH032511 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | BMP-11, Bone morphogenetic protein 11, GDF-11, Growth/differentiation factor 11 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Asn299-Ser407 |
| Accession | O95390 |
| Calculated Molecular Weight | 12.5 kDa |
| Observed Molecular Weight | 13-20 kDa |
| Tag | None |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 50% glycerol, pH 7.4. |
| Reconstitution | Not Applicable |
Background
Growth/differentiation factor 11(GDF-11) is a secreted protein, which belongs to the transforming growth factor beta superfamily. GDF-11 controls anterior-posterior patterning by regulating the expression of Hox genes. The secreted signal acts globally to specify positional identity along the anterior/posterior axis during development. GDF11 has been shown to suppress neurogenesis through a pathway similar to that of myostatin, including stopping the progenitor cell-cycle during G-phase. The similarities between GDF11 and myostatin imply a likelihood that the same regulatory mechanisms are used to control tissue size during both muscular and neural development.