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Recombinant Human GFRRA2 Protein ((Fc & His Tag)– MSE Supplies LLC

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Recombinant Human GFRRA2 Protein ((Fc & His Tag)

SKU: PKSH032482-50

  • $ 11695
  • Save $ 1300



Recombinant Human GFRRA2 Protein ((Fc & His Tag)

 

SKU # PKSH032482
Expression Host HEK293 Cells

 

 

Description

Synonyms GDNF Family Receptor Alpha-2, GDNF Receptor Alpha-2, GDNF Receptor Beta, GDNFR-Alpha-2, GDNFR-Beta, GDNFRB, GFR-Alpha-2, GFRA2, NRTNR-Alpha, NTNR-Alpha, Neurturin Receptor Alpha, RET Ligand 2, RETL2, TGF-Beta-Related Neurotrophic Factor Receptor 2, TRNR2
Species Human
Expression Host HEK293 Cells
Sequence Ser22-Ser441
Accession O00451
Calculated Molecular Weight 74.7 kDa
Observed Molecular Weight 120 kDa
Tag C-Fc-His
Bio-activity Not validated for activity
  

 

Properties

Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.



Background

GDNF family receptor alpha-2 is a glycosylphosphatidylinosito l (GPI)-linked cell surface receptor. It is part of the GDNF receptor family. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFRA2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor. It also able to mediate GDNF signaling through the RET tyrosine kinase receptor. It acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1.