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Recombinant Human GFRRA2 Protein (His Tag)
SKU: PKSH033430-50
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Recombinant Human GFRRA2 Protein (His Tag)
| SKU # | PKSH033430 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | GDNF Family Receptor Alpha-2, GDNF Receptor Alpha-2, GDNF Receptor Beta, GDNFR-Alpha-2, GDNFR-Beta, GDNFRB, GFR-Alpha-2, GFRA2, NRTNR-Alpha, NTNR-Alpha, Neurturin Receptor Alpha, RET Ligand 2, RETL2, TGF-Beta-Related Neurotrophic Factor Receptor 2, TRNR2 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Ser22-Ser441 |
| Accession | O00451 |
| Calculated Molecular Weight | 47.8 kDa |
| Observed Molecular Weight | 80 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Members of the glial cell line-derived neurotrophic factor (GDNF) family, including GDNF and Neurturin, play key roles in the control of vertebrate neuronal survivial and differentiation. GDNF is a glycosylated, disulfide-bonded homodimer that is distantly related to the TGF superfamily of growth factors. Three receptors for these factors, GFRα-1, GFRα-2, and GFRα-3 have been identified. The receptors do not contain transmembrane domains and are attached to the cell membrane by glycosyl-phosphoinositol linkage. Both GFRα-1 and GFRα-2 have been shown to mediate the GDNF-dependent and Neurturin-dependent phosphorylation and activation of the tyrosine kinase Ret. GFR-3 is expressed only during development. GFRα-2 binds Neurturin and mediates activation of RET receptor tyrosine kinase by both Neurturin and GDNF.