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Recombinant Human GMPR Protein (Human Cells, His Tag)
SKU: PKSH033290-50
Recombinant Human GMPR Protein (Human Cells, His Tag)
| SKU # | PKSH033290 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | GMP Reductase 1, GMPR, GMPR1, Guanosine 5'-Monophosphate Oxidoreductase 1, Guanosine Monophosphate Reductase 1 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Met 1-Ser345 |
| Accession | AAH08281.1 |
| Calculated Molecular Weight | 38.5 kDa |
| Observed Molecular Weight | 40 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 40% Glycerol, 150mM NaCl, 1mM DTT, pH 8.0. |
| Reconstitution | Not Applicable |
Background
GMP Reductase 1 (GMPR) is a member of the IMPDH/GMPR family. GMPR exists as a homotetramer and catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase; nucleoside and nucleotide derivatives of G to A nucleotides; and in maintaining the intracellular balance of A and G nucleotides. GMP reductase gene expression may be regulated by MITF. At least two different alleles are known.