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Recombinant Human HIP2/UBE2K Protein (GST Tag)
SKU: PKSH033187-50
Recombinant Human HIP2/UBE2K Protein (GST Tag)
| SKU # | PKSH033187 |
| Expression Host | E.coli |
Description
| Synonyms | HIP-2, HIP2, Huntingtin-Interacting Protein 2, LIG, UBE2K, Ubiquitin Carrier Protein, Ubiquitin-Conjugating Enzyme E2 K, Ubiquitin-Conjugating Enzyme E2(25K), Ubiquitin-Conjugating Enzyme E2-25 kDa, Ubiquitin-Conjugating Enzyme E2-25K, Ubiquitin-Protein Ligase |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Asn200 |
| Accession | P61086 |
| Calculated Molecular Weight | 48.7 kDa |
| Observed Molecular Weight | 45 kDa |
| Tag | N-GST |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 50mM HEPES, 150mM NaCl, 2mM DTT, 10% Glycerol, pH 7.5. |
| Reconstitution | Not Applicable |
Background
Ubiquitin-Conjugating Enzyme E2 K (UBE2K) belongs to the E2 Ubiquitin-Conjugating Enzyme family. UBE2K is highly expressed in the brain; with highest levels found in cortex and striatum; and at lower levels in cerebellum and brainstem. UBE2K may mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. UBE2K is associated with the selective degradation of short-lived and abnormal proteins; such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. In addition; UBE2K is involved in Alzheimer's disease; Huntington's disease and antigen processing through its interaction with huntingtin; and MHC-heavy chain proteins.