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Recombinant Human HSPB2/MKBP Protein (His Tag)
SKU: PKSH032523-50
Recombinant Human HSPB2/MKBP Protein (His Tag)
| SKU # | PKSH032523 |
| Expression Host | E.coli |
Description
| Synonyms | DMPK-binding protein, Heat shock protein beta-2, HspB2, MKBP |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Pro182 |
| Accession | Q16082 |
| Calculated Molecular Weight | 21.3 kDa |
| Observed Molecular Weight | 22-25 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 10mM Tris-HCl, 150mM NaCl, 1mM EDTA, pH 8.0. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Heat shock protein beta-2(HSPB2) is a protein that in humans is encoded by the HSPB2 gene. HSPB2 belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. It is expressed preferentially in the heart and skeletal muscle. HSPB2 has been shown to interact with TRAF6, HSPB8, Myotonic dystrophy protein kinase and CRYAB. HSPB2 regulates Myotonic Dystrophy Protein Kinase, which plays an important role in maintenance of muscle structure and function.