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Recombinant Human IA2/PTPRN Protein (aa 607-Asn686 & aa 795-888, His Tag)
SKU: PKSH032555-50
Recombinant Human IA2/PTPRN Protein (aa 607-Asn686 & aa 795-888, His Tag)
| SKU # | PKSH032555 |
| Expression Host | E.coli |
Description
| Synonyms | ICA 512, ICA3, ICA512, Islet cell antigen 512, Islet cell autoantigen 3, PTP IA-2, PTPRN, R-PTP-N, Receptor-type tyrosine-protein phosphatase-like N |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Gln607-Asn686&Trp795-Leu888 |
| Accession | Q16849 |
| Calculated Molecular Weight | 22.9 kDa |
| Observed Molecular Weight | 26-30 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM DTT, 1mM EDTA, pH 8.0. |
| Reconstitution | Not Applicable |
Background
Receptor-type tyrosine-protein phosphatase-like N (PTPRN) belongs to the protein-tyrosine phosphatase family and receptor class 8 subfamily. PTPRN contains 1 tyrosine-protein phosphatase domain; is expressed in neuroendocrine cells only. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth; differentiation; mitotic cycle; and oncogenic transformation. It implicated in neuroendocrine secretory processes. It may be involved in processes specific for neurosecretory granules; such as their biogenesis; trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. It seems to lack intrinsic enzyme activity; may play a role in the regulation of secretory granules via its interaction with SNTB2. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera; and thus may be a potential target of autoimmunity in diabetes mellitus.