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Recombinant Human IFN-λ1/IL-29 Protein (His Tag)
SKU: PKSH033639-50
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Recombinant Human IFN-λ1/IL-29 Protein (His Tag)
| SKU # | PKSH033639 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | IFN-lambda, Interleukin, ytokine Zcyto, Cytokine Zcyto, IFNL, ZCYTO, IFN-λ, lambda, Cytokine Zcyto21, IFN-lambda-1, IFN-λ1, IL-29, interferon, interferon lambda 1, Interferon lambda-1, Interleukin-29, lambda 1, ytokine Zcyto21, IL29, ZCYTO21, IFNL1 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Gly20-Thr200 |
| Accession | Q8IU54 |
| Calculated Molecular Weight | 21.4 kDa |
| Observed Molecular Weight | 28-35 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Interleukin-29 (IL-29) is a secreted protein which belongs to the IL-28/IL-29 family. IL-29 is a cytokine with immunomodulatory activity. IL-29 is highly similar in amino acid sequence to the IL-28. IL-28 and IL-29 are induced by viral infection and showed antiviral activity. IL-28 and IL-29 interacted with a heterodimeric class II cytokine receptor that consisted of IL-10 receptor beta (IL-10R beta) and an orphan class II receptor chain, designated IL-28R alpha. IL-29 plays an important role in host defenses against microbes and its gene is highly upregulated in cells infected with viruses. IL-29 may play a role in antiviral immunity. IL-29 up-regulates MHC class I antigen expression. It is a Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway.