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Recombinant Human IFNGR1 Protein (His Tag)
SKU: PKSH033429-50
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Recombinant Human IFNGR1 Protein (His Tag)
| SKU # | PKSH033429 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | CD119, IFNGR, IFNGR1, IMD27A, IMD27B, Interferon gamma receptor 1 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Glu18-Ser245 |
| Accession | P15260 |
| Calculated Molecular Weight | 26.8 kDa |
| Observed Molecular Weight | 40-50 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
| Reconstitution | Not Applicable |
Background
Interferon gamma receptor 1(IFNGR1) encoded by the IFNGR1 gene, is a single-pass type 1 membrane protein which belongs to the type II cytokine receptor family. IFNGR1 is phosphorylated at Ser/Thr residues after translation. IFNGR1 is a receptor for interferon gamma, two receptors bind one interferon gama dimer. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection.