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Recombinant Human IGFBP3 Protein(His tag)
SKU: PDMH100044-100
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Recombinant Human IGFBP3 Protein(His tag)
| SKU # | PDMH100044 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | IBP-3, IGF-binding protein 3, IGFBP-3 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Met1-Lys291 |
| Accession | P17936 |
| Calculated Molecular Weight | 32.5 kDa |
| Observed Molecular Weight | 38-42 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 80 % as determined by reducing SDS-PAGE. |
| Endotoxin | Please contact us for more information. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis |
Background
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Inhibits the positive effect of humanin on insulin sensitivity.Promotes testicular germ cell apoptosis.