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Recombinant Human IL-1A/IL-1α Protein
SKU: PKSH033458-100
Recombinant Human IL-1A/IL-1α Protein
| SKU # | PKSH033458 |
| Expression Host | E.coli |
Description
| Synonyms | IL1F, IL1A, IL-1A, IL1, IL1-ALPHA, IL1F1, BAF, FAF, Hematopoietin 1, Hematopoietin-1, IL 1 alpha, IL 1A, IL1 ALPHA, IL-1 alpha, IL1-A, Interleukin 1 alpha, Interleukin1 alpha, Interleukin-1 alpha, LAF, LEM, Preinterleukin 1 alpha, Pro interleukin 1 alpha, Pro-Interleukin-1-Alpha |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Ser113-Ala271 |
| Accession | P01583 |
| Calculated Molecular Weight | 19 kDa |
| Observed Molecular Weight | 17 kDa |
| Tag | C-His |
| Bio-activity | Measure by its ability to induce D10.G4.1 cells proliferation.The ED50 for this effect is <10 pg/mL. The specific activity of recombinant human IL-1 alpha is approximately >1x108IU/ mg. |
Properties
| Purity | > 98 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 0.1 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS,pH 8.0. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Interleukin-1 alpha (IL1α) is a cytokine member of the interleukin-1 family. IL-1 consists of two distinct forms: IL1α and IL1β that recognize the same cell surface receptors but are distinct proteins with approximately 25% amino acid sequence identity. IL1α is constitutively produced by epithelial cells and plays an essential role in maintenance of skin barrier function. Upon stimulation, a wide variety of cells including osteoblasts, monocytes, macrophages can be induced to express IL1α. IL1α possesses a wide range of metabolic, physiological, haematopoietic activities, and is critically involved in the regulation of the immune responses and inflammatory responses.