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Recombinant Human IL-1R8/IL1RAPL1 Protein (aa 19-357, His Tag)
SKU: PKSH033634-50
Recombinant Human IL-1R8/IL1RAPL1 Protein (aa 19-357, His Tag)
| SKU # | PKSH033634 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | IL1R, OPHN, TIGIRR, MRX, IL1RAPL1, IL1R8, IL1RAPL, MRX10, MRX21, MRX34, OPHN4, TIGIRR-2, IL1RAPL-1, IL-1RAPL-1, IL-1-RAPL-1, Interleukin-1 Receptor Accessory Protein-Like 1, Oligophrenin-4, Three Immunoglobulin Domain-Containing IL-1 Receptor-Related 2, X-Linked Interleukin-1 Receptor Accessory Protein-Like 1 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Leu19-Val360 |
| Accession | Q9NZN1 |
| Calculated Molecular Weight | 40 kDa |
| Observed Molecular Weight | 50-60 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Interleukin-1 receptor accessory protein-like 1; also known as IL1RAPL1; can be detected at low levels in heart; skeletal muscle; ovary; skin; amygdala; caudate nucleus; corpus callosum; hippocampus; substantia nigra and thalamus. IL1RAPL1 functions as a homodimer; it interacts with NCS1; PTPRD. This interaction is PTPRD-splicing-dependent and induces pre- and post-synaptic differentiation of neurons and is required for IL1RAPL1-mediated synapse formation. During dendritic spine formation; it can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD.